Treatment options for diabetes type 2

Diabetes type 2 is metabolic disorder, which is caused by lack of insulin or insulin resistance. That means that there is normal secretion of insulin in your organism and it is not enough to reduce the glucose in plasma or it is not able to reduce it. The treatment of diabetes type 2 is separated according to the stage of disorder. If the diabetes is at early stages of the usage of oral anti-diabetic drugs obligatory. Besides this bariatric surgery is something that may help. At the advanced stages of diabetes type 2 the usage of insulin is needed.

Oral anti-diabetic drugs are not containing insulin. These drugs are divided in three groups according to their effect. The drugs from the first group are stimulating the insulin secretion of pancreas. Those drugs are quite useful when there is a reduction in the insulin secretion. The second group is reducing the insulin resistance. These drugs are stimulating the effect of the insulin- to reduce the amount of glucose in plasma by putting it in the cells. The last group is composed of drugs which are reducing the amount of glucose which is entering in the organism from the gastrointestinal system. Those drugs are blocking the channels thru which the glucose enters the blood stream.

In addition,  there are drugs which are having more than one effect. For example some drugs are reducing the insulin resistance and at the same time they are stimulating the insulin secretion.

Bariatric surgery is focused on reducing the volume of stomach. With this operation it is reduced the surface thru which glucose enters the blood stream. This is leading to lower amount of glucose and lower blood sugar. This kind of therapy is useful remedy at the early stages of diabetes type 2.

The usage of insulin is observed in the advanced stages of diabetes type 2. Because of the continuous beta cells destruction at some point all the beta cells are gone. That means that there is no insulin secretion and the only way to provide insulin for the body is by injecting it.

 

Dr.Alba

When is it best not to test your blood glucose level?

If you are not diabetic, it’s obligatory for you to test you blood sugar when you are hungry, to make fasting glucose test. When you are making blood glucose test after acquiring food ,your blood sugar level is going to be elevated. A result like this will make your doctor thing that you are diabetic.

The explanation of this is hidden in the glucose metabolism. When you are eating something, all sugar is going to your blood stream and this leads to elevation of the blood sugar. The elevation of blood sugar is leading to increased secretion of insulin, which is lowering the amount of glucose in plasma, and increases the amount of glucose in all the tissues. As you probably know, the secretion and the effect of the insulin requires time. For that reason before the secretion of insulin you have elevation of blood sugar level, which is characteristic for diabetics.

If you are diabetic you are supposed to estimated blood sugar test, according to a specific schedule provided by your doctor. It is good for you to write down the values of blood glucose and the exact time of measurement. Besides this, you have to mention the exact time of acquiring food. This will absolutely help you doctor to adjust the therapy in purpose to maintain blood sugar level in normal range.

 

Dr.Alba

Blood glucose level drops to 56

The normal glucose range is between 70-100mg/dl. A blood glucose level of 56 is pretty low. Such low blood glucose level is prescribed by the term hypoglycemia. There are several medical conditions which are characterized by such low blood glucose. In purpose to confirm them, there are a lot of test that need to be estimated.

  • The most frequent condition which is causing low blood glucose is malnutrition. As you probably know, making a diet is connected with the reduction of food acquired. That is leading to limitation of the glucose which is entering in the organism. Of course, the organism is having some compensatory mechanisms which are leading to an elevation of the blood glucose level. These mechanisms are not able to maintain the normal blood glucose level forever and this lead to permanent reduction of the glucose in your organism. This is leading to the development of anorexia, pretty dangerous condition which is appearing as a consequence of malnutrition. For that reason, when someone wants to follow a diet, he has to consult a dietologist first.
  • Other possible condition which may cause such low blood sugar is the presence of insulinoma. This is a type of cancer secreting extra insulin, which the organism doesn’t need. The excessive amount of insulin is lowering your blood glucose level and the hormones which are responsible for the of blood glucose elevation are not able to beat the effect of so much insulin.

Hypoglycemia is causing other symptoms which are leading the patient to the doctor. For example when there is hypoglycemia you are felling exhausted, a headache is appearing and your blood pressure is high. These symptoms are appearing because the organism is trying to compensate the lack of glucose by increasing the blood flow in the important areas like brain heart and lungs.

Dr.Alba

What does a glucose level of 314 in a blood test mean?

A glucose level of 314 in a blood test mean that there is an elevation of your blood glucose level. The normal range of blood glucose is about 70-100 mg/dl or 3.5-5.6mmol/l depending on the schedule which is used. It is important to see if this elevation is observed before or after having a meal. Eating something very sweet may cause an elevation of blood glucose like this. The only option in here is to eat chocolate for example about 30 minutes before the blood test. In purpose to avoid result like this, doctors are forbidding their patients to eat before the blood test.

If this elevation is observed after having a meal that means that your organism is having difficulties with the glucose metabolism. If this result is appeared when you were hungry that means that your organism is not capable to handle with the glucose. In purpose to confirm diagnose diabetes there are several other test which have to be estimated. Besides this, high glucose level is not the only one symptom occurred in patients with diabetes. Increased thirst, hunger and urination are the three major symptoms which are met in patients with diabetes

In general, patients with an elevation of blood glucose like this are diagnosed with diabetes. This result is saying that there is something abnormal in the glucose metabolism. This abnormality may become as a result of impaired glucose tolerance or because of reduction of the insulin secretion. In both situations you have to control your blood glucose level by taking pill or injecting insulin.

Dr.Alba

At what blood glucose level do you see increased urination?

Glucose, in general, is an osmotic substance, which means that glucose attracts water. The organism is trying to maintain the concentration of glucose in range between 3.5-5.6mmo/l. Small deviations in this range, are lading to changes in the whole organism.

As you may know, increased urination is one of the first three symptoms of diabetes. The other two symptoms are increased thirst and increased appetite. The increased urination is observed when the glucose level is higher than 6.8mmol/l. The explanation of this fact is related with the increased blood’s osmolality. The glucose is passing from the blood to the urine compartment in the kidney. When a major part of the glucose is in the urine compartment, because of its osmotic ability, it attracts the water from the blood. This generally leads to increased amount of urine and loss of water. This water loss is stimulating the thirst center, which is making us to drink more water. In that way the organism is trying to compensate the amount of water lost.

When your blood glucose level fell to 5.6mmol/l, the increased urination is stopping, because the glucose is in normal amount. There is no excessive glucose to attract the water from the blood and to increase the urination. The fell of the blood glucose level is observed when you are hungry. When you acquire food you are increasing the amount of glucose in your organism. Because there is not enough insulin to put this glucose in to the cells, it gets excreted by the urine, which of course is leading to increased urination. For that reason, the increased urination as a symptom is observed in the post-prandial period. The increased urination is the only option for the organism to reduce the amount of glucose.

Dr.Alba

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What is the highest blood glucose level before damage is set?

The organism is having a lot of ways to compensate the elevated amount of sugar in your blood. Because of this fact, the highest blood sugar level ever measured in a live human being is 311.3mmol/l. The bad thing  is that every organism has different ability to compensate the elevated blood sugar level.

According to data provided by the latest researches on this topic, a blood sugar level consistently higher than 5.6mmol/l is causing organ damages. Organ damages are occurred if you are maintaining higher than this value for over a month or two. The damages of the organs are appearing because the compensatory reactions of the organism are not able to protect all organs from the bad affect the high amount of sugar in plasma.

In general, nerve cells are those who are most sensitive at the effect of high blood sugar. For that reason, when the level of the blood sugar is higher than 7.2mmol/l, the nerve damages are starting. This happens because the nerve cells are the most active of all cells in the organism. Therefore, small changes in the amount of glucose or oxygen is destroying their activity. Besides this, the nerve cells of the peripheral nerves are those who are suffering the most. The elevated amount of glucose is destroying the myelin membrane of nerve cells. This destruction is slowing the transition of the signal, which leads to the reduction of the sensitivity, a condition  known as peripheral polyneuropathy.

The nerve cells of the brain are protected from the HEB (hematoencephal barrier). This barrier is controlling the amount of glucose which is going from the blood to the brain. For that reason, if there is an elevation of the blood sugar in plasma, only the needed amount of glucose goes to the brain.

Dr.Alba

Can you provide some clinical trials islet-cell transplants for diabetes and related references?

There is one very successful two part study. The first part of study was estimated in April 2001. This study was trying to discover the affect of b-cells transplant in individuals with diabetes type 1. The aim was to see if there are some side affect which may cause the death of the particular individuals. This study was testing the ability of beta cells of the transplant to replace the insulin treatment of diabetes type 1.

This study was pretty successful and the only thing that really mater is the immunological profile of the individual diabetes and the donor’s immunological profile. There are some particular criteria which have to be fulfilled in purpose to protect the health of the patient. After the transplantation the insulin treatment of those patients was stopped and more then 50% of them were normal amount of blood sugar in the organism. That means that this is a pretty good way to treat this disease. The rest of the patients were put back to insulin therapy because their b-cells weren’t secreting enough insulin for their needs.

There are two important facts in here, which are explaining the results. First of all, important for this type of therapy is the stage of diabetes type 1, because when you are having diabetes from 15- years or more this treatment is not useful and the insulin is the only way. The explanation of this is that with the passage of years the destruction of the beta cells is continuing. After 15 years for example there are only few beta cells in your pancreas which are unable to ensure the amount of insulin, including the beta cells transplanted to the organism. For that reason the scientist are thinking of a way to transplant more beta cells in people who are suffering from diabetes more then 10-15 years.

The second part of this study was trying to confirm the result from the first part. This study was closed at March this year and the results were the same as those from the first part. That means that this study can continue to the next step of testing.

Dr.Alba

What can you take to control your blood sugar levels?

The blood sugar level is controlled by several things which can be divided in two groups: inside factors and outside factors.

  • Inside factors include the hormones that control the blood sugar. Each of these hormones has a specific function, some of them increase the blood glucose and only one of them reduces the blood glucose – insulin. When your organism can not produce insulin, you are prescribed to inject it or to take pills which are stimulating the production of glucose.
  • The outside factors are quite a large group which is composed of all foods and drinks. Important for you to control your blood sugar is to eat foods which are not rich in carbohydrates, because they are going to increase your blood sugar immediately.

Other than that, keep in mind that all the meals that are oily are forbidden for diabetics and not highly recommended for the others. Beside this, you are supposed not to take something that may increase the amount of sugar in your blood by blocking the metabolic reactions. Some substances like alcohol are increasing the blood sugar level, because these beverages contain sugar and ethanol (methanol). The ethanol is blocking the metabolic reactions related with the fragmenting of the sugar and this leads to increased amount of sugar in your blood.

As you may see, the majority of actions to control diabetes depend on you. Please be consistent and never give up!

Dr.Alba

Any clinical evidence shows that more children with asthma are obese?

There are a lot of clinical trials, which are studying the relationship between asthma and obesity in kids.

First of all, you must understand that there are a lot of risk factors for the development of asthma or obesity and the most important one is the family history.

With regards to some clinical trials showing that the number of asthmatic children with obesity is growing, there exist many explanations on this phenomenon; however none of them is considered as true.

  1. First of all, the researchers suppose that asthmatic kids are not moving enough, and they are not doing enough exercises, because they are afraid of asthmatic attacks. This is just explainable because they aren’t used with their condition and they don’t know how to handle with it.
  2. Besides this, some of the medications used for the treatment of asthma are decreasing the metabolism and that leads to the accumulation in the cells of the fat tissue. This of course is leading to a gaining of weight and obesity.
  3. However there is another hypothesis stating that obesity comes first and then the asthma. The explanation in here is that the increased amount of fat acids in the organism is increasing the hypersensitivity of the air ways. Of course none of the scientists which are working on this topic can say which comes first the asthma or the obesity. But we have the result- exaggerated number of children with asthma are becoming with a weight above the standard.

Dr.Alba